Polyphemus

Isaac fires huge tears that deal massive damage but fire rate is greatly decreased. If a tear kills an enemy, the tear travels on with any leftover damage.

Quote

"Mega Tears"

Effects

• Greatly increased damage:
• Tears down:
• If a tear kills an enemy, the tear travels on with any leftover damage.

Synergies

• Dr. Fetus - Increases tear delay, and after the first bomb explodes, a second bomb appears where the first one exploded, doing roughly half the damage of the first.
• The Inner Eye - The tear rate is not lowered further, but the effect on damage becomes a flat +5 bonus instead.
• Mutant Spider - The tear rate is not lowered further, but the effect on damage becomes a flat +5 bonus instead.
• Shard of Glass - The rapidly spawning red tears do full damage.

Found in

• Treasure Room
• Treasure Room (Greed Mode)